Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.41 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16083527 | 0.75 | EHMT2 (0.49) | PDGFRBPDGFRAKDREHMT2EHMT1 | |
| SCHEMBL14310926 | 0.75 | EHMT2 (0.49) | PDGFRBPDGFRAKDREHMT2EHMT1 | |
| SCHEMBL16070093 | 0.74 | EHMT2 (0.50) | PDGFRBPDGFRAKDREHMT2EHMT1 | |
| SCHEMBL9609153 | 0.74 | MET (0.49) | PDGFRBPDGFRAMETFGFR2 | |
| SCHEMBL10189194 | 0.73 | ENPP1 (0.56) | PDGFRBPDGFRAKDREHMT2EHMT1 | |
| SCHEMBL10188763 | 0.73 | ENPP1 (0.56) | PDGFRBPDGFRAKDREHMT2EHMT1 | |
| SCHEMBL14139343 | 0.72 | PDGFRA (0.61) | PDGFRBPDGFRAKDRFGFR2 | |
| SCHEMBL14139303 | 0.72 | PDGFRA (0.61) | PDGFRBPDGFRAKDRFGFR2 | |
| SCHEMBL21299301 | 0.72 | PDGFRA (0.50) | PDGFRBPDGFRAKDRFGFR2SRC | |
| SCHEMBL20096381 | 0.71 | MET (0.46) | PDGFRBPDGFRAMETKDREHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2018-06-06 | — | — | EP | disclosed |