Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 5/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217295 | 0.86 | SMN1; SMN2 (0.47) | HDAC1MEN1ALDH1A1KMT2A | |
| SCHEMBL20217236 | 0.84 | HDAC3 (0.44) | HDAC2HDAC3HDAC1KCNK3F10 | |
| SCHEMBL20217262 | 0.81 | F10 (0.46) | HDAC2HDAC3HDAC1KCNK3F10 | |
| SCHEMBL20217694 | 0.79 | MEN1 (0.47) | F10MEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL20217743 | 0.78 | MEN1 (0.45) | F10MEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL20217335 | 0.78 | F10 (0.43) | KCNK3F10MEN1ALDH1A1MAPK1 | |
| SCHEMBL20217296 | 0.77 | TTK (0.50) | F10MEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL20217747 | 0.77 | CYP3A4 (0.47) | KCNK3F10MEN1ALDH1A1MAPK1 | |
| SCHEMBL20217712 | 0.76 | F10 (0.44) | KCNK3F10MEN1ALDH1A1MAPK1 | |
| SCHEMBL20217185 | 0.76 | AKT1 (0.43) | HDAC2HDAC3HDAC1KCNK3F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |