Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SLC5A7 | Q9GZV3 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217221 | 0.90 | TTK (0.51) | TTKCYP3A4AURKBINCENPLMNA | |
| SCHEMBL20217268 | 0.89 | MEN1 (0.47) | TTKCYP3A4AURKBINCENPLMNA | |
| SCHEMBL20217198 | 0.87 | CYP3A4 (0.52) | TTKCYP3A4AURKBINCENPLMNA | |
| SCHEMBL20217290 | 0.86 | ALDH1A1 (0.49) | TTKCYP3A4AURKBINCENPLMNA | |
| SCHEMBL20217747 | 0.84 | CYP3A4 (0.47) | TTKCYP3A4AURKBINCENPLMNA | |
| SCHEMBL20217390 | 0.84 | TTK (0.63) | TTKCYP3A4AURKBINCENPLMNA | |
| SCHEMBL20217292 | 0.82 | TTK (0.39) | TTKCYP3A4AURKBINCENPLMNA | |
| SCHEMBL20217295 | 0.81 | SMN1; SMN2 (0.47) | LMNAALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL20217409 | 0.81 | LMNA (0.44) | TTKCYP3A4LMNAALDH1A1SLC5A7 | |
| SCHEMBL20217694 | 0.81 | MEN1 (0.47) | TTKCYP3A4AURKBINCENPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |