Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217149 | 0.93 | KCNA5 (0.41) | HDAC6SLC6A2SLC6A4SLC6A3KCNA5 | |
| SCHEMBL20217274 | 0.93 | KCNA5 (0.41) | HDAC6SLC6A2SLC6A4SLC6A3KCNA5 | |
| SCHEMBL14873381 | 0.77 | KCNA5 (0.42) | HDAC6SLC6A2SLC6A4SLC6A3KCNA5 | |
| SCHEMBL24214835 | 0.77 | SETD2 (0.34) | KDM4ENPSR1ALDH1A1 | |
| SCHEMBL20851461 | 0.76 | TSHR (0.47) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL20851462 | 0.76 | TSHR (0.47) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL20851460 | 0.76 | TSHR (0.47) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL23970339 | 0.75 | SLC6A2 (0.47) | HDAC6SLC6A2SLC6A4SLC6A3KCNA5 | |
| SCHEMBL14863636 | 0.73 | L3MBTL1 (0.46) | HDAC6FFAR2KDM4ENPSR1CYP3A4 | |
| SCHEMBL14863635 | 0.73 | L3MBTL1 (0.46) | HDAC6FFAR2KDM4ENPSR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |