Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20413271 | 0.94 | TLR8 (0.36) | CRHR1FFAR1TLR8TLR7PFKFB3 | |
| SCHEMBL15470290 | 0.90 | TLR8 (0.42) | TLR8TLR7 | |
| SCHEMBL20386695 | 0.90 | TLR8 (0.42) | TLR8TLR7 | |
| SCHEMBL20219745 | 0.87 | KCNH2 (0.39) | CRHR1FFAR1TLR8TLR7 | |
| SCHEMBL23472388 | 0.86 | CRHR1 (0.33) | CRHR1FFAR1TLR8TLR7 | |
| SCHEMBL23472615 | 0.86 | FFAR1 (0.36) | CRHR1FFAR1TLR8TLR7DAO | |
| SCHEMBL20219389 | 0.84 | TLR8 (0.43) | TLR8TLR7 | |
| SCHEMBL15469724 | 0.84 | TLR8 (0.43) | TLR8TLR7 | |
| SCHEMBL15470318 | 0.83 | KCNH2 (0.45) | TLR8TLR7 | |
| SCHEMBL23472482 | 0.81 | TLR8 (0.33) | FFAR1TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |