Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 17/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 13/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472165 | 1.00 | TLR8 (0.51) | TLR8TLR7L3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL23472330 | 0.96 | TLR8 (0.47) | TLR8TLR7L3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL20219677 | 0.84 | SRC (0.41) | TLR8TLR7L3MBTL1 | |
| SCHEMBL23472353 | 0.83 | NPSR1 (0.39) | TLR8TLR7L3MBTL1 | |
| SCHEMBL20219338 | 0.82 | TLR8 (0.50) | TLR8TLR7L3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL23472328 | 0.81 | SRC (0.45) | TLR8TLR7L3MBTL1 | |
| SCHEMBL20219716 | 0.81 | SRC (0.45) | TLR8TLR7L3MBTL1 | |
| SCHEMBL17035546 | 0.79 | TLR8 (0.62) | TLR8TLR7L3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL15469963 | 0.78 | TLR8 (0.50) | TLR8TLR7L3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL13195744 | 0.78 | TLR8 (0.50) | TLR8TLR7L3MBTL1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |