Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.33 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21768408 | 0.82 | KCNH2 (0.52) | KCNH2TLR8TLR7 | |
| SCHEMBL15470391 | 0.82 | KCNH2 (0.52) | KCNH2TLR8TLR7 | |
| SCHEMBL23472197 | 0.81 | TLR8 (0.41) | KCNH2TLR8TLR7BRD4BRD2 | |
| SCHEMBL15470177 | 0.79 | TLR8 (0.49) | KCNH2TLR8TLR7 | |
| SCHEMBL20219461 | 0.79 | TLR8 (0.37) | KCNH2TLR8TLR7BRD4BRD2 | |
| SCHEMBL20219636 | 0.76 | KCNH2 (0.51) | KCNH2TLR8TLR7 | |
| SCHEMBL15470229 | 0.76 | KCNH2 (0.51) | KCNH2TLR8TLR7 | |
| SCHEMBL20219726 | 0.76 | TLR8 (0.43) | KCNH2TLR8TLR7 | |
| SCHEMBL20219711 | 0.75 | TLR8 (0.44) | KCNH2TLR8TLR7 | |
| SCHEMBL20219778 | 0.74 | TLR7 (0.41) | KCNH2TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |