Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472205 | 0.86 | TLR8 (0.41) | TLR8TLR7CDK1CDK5 | |
| SCHEMBL15470171 | 0.85 | TLR8 (0.48) | TLR8TLR7KCNH2 | |
| SCHEMBL20219566 | 0.84 | TLR8 (0.37) | TLR8TLR7KCNH2CDK1CDK5 | |
| SCHEMBL23472197 | 0.81 | TLR8 (0.41) | TLR8TLR7CCNKCDK12KCNH2 | |
| SCHEMBL23472650 | 0.81 | CRHR1 (0.34) | TLR8TLR7CRHR1 | |
| SCHEMBL23472657 | 0.81 | TLR8 (0.41) | TLR8TLR7CDK1CDK5 | |
| SCHEMBL23472555 | 0.81 | TRPM8 (0.41) | TLR8TLR7KCNH2 | |
| SCHEMBL15470177 | 0.80 | TLR8 (0.49) | TLR8TLR7KCNH2 | |
| SCHEMBL23472369 | 0.79 | TLR8 (0.38) | TLR8TLR7KCNH2CDK1CDK5 | |
| SCHEMBL20219649 | 0.79 | KCNH2 (0.38) | TLR8TLR7KCNH2BRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |