Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19562723 | 0.85 | EPHB3 (0.54) | EPHB3KDM4EALDH1A1POLBGLA | |
| SCHEMBL20220373 | 0.83 | EPHB3 (0.46) | EPHB3KDM4EALDH1A1POLBGLA | |
| SCHEMBL16292809 | 0.83 | NTRK1 (0.41) | — | |
| SCHEMBL15039643 | 0.83 | NTRK1 (0.41) | — | |
| SCHEMBL15039748 | 0.81 | NTRK1 (0.47) | — | |
| SCHEMBL16292726 | 0.81 | NTRK1 (0.47) | — | |
| SCHEMBL20220366 | 0.78 | EPHB3 (0.59) | EPHB3KDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL19562926 | 0.78 | EPHB3 (0.55) | EPHB3KDM4EALDH1A1GLAHTT | |
| SCHEMBL20220418 | 0.77 | EPHB3 (0.54) | EPHB3KDM4EALDH1A1IRAK4CREBBP | |
| SCHEMBL19562661 | 0.77 | EPHB3 (0.55) | EPHB3SMN1; SMN2IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791138-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | Dr Reddys Laboratories Ltd (IN) | 2018-06-06 | — | — | EP | disclosed |