Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.37 |
| ▸ | FLT3 | P36888 | 4/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19562927 | 0.86 | EPHB3 (0.56) | EPHB3IRAK4FLT3L3MBTL1 | |
| SCHEMBL20220366 | 0.86 | EPHB3 (0.59) | EPHB3FLT3L3MBTL1 | |
| SCHEMBL16292524 | 0.84 | NTRK1 (0.43) | — | |
| SCHEMBL15039642 | 0.84 | NTRK1 (0.43) | — | |
| SCHEMBL16292929 | 0.83 | NTRK1 (0.51) | — | |
| SCHEMBL15039640 | 0.83 | NTRK1 (0.51) | — | |
| SCHEMBL19562597 | 0.80 | EPHB3 (0.57) | EPHB3IRAK4FLT3 | |
| SCHEMBL20220418 | 0.79 | EPHB3 (0.54) | EPHB3USP30IRAK4KEAP1NFE2L2 | |
| SCHEMBL19562733 | 0.79 | EPHB3 (0.59) | EPHB3FLT3GFERL3MBTL1 | |
| SCHEMBL19562568 | 0.76 | EPHB3 (0.50) | EPHB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791138-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | Dr Reddys Laboratories Ltd (IN) | 2018-06-06 | — | — | EP | disclosed |