Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 7/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16547096 | 0.94 | THRB (0.50) | TSHRHPGDTHRBS1PR5SMN1; SMN2 | |
| SCHEMBL22446246 | 0.94 | THRB (0.50) | TSHRHPGDTHRBS1PR5SMN1; SMN2 | |
| SCHEMBL18876412 | 0.94 | THRB (0.50) | TSHRHPGDTHRBS1PR5SMN1; SMN2 | |
| SCHEMBL12090760 | 0.94 | THRB (0.50) | TSHRHPGDTHRBS1PR5SMN1; SMN2 | |
| SCHEMBL25485983 | 0.94 | THRB (0.60) | TSHRHPGDTHRBS1PR5LMNA | |
| SCHEMBL25485982 | 0.94 | THRB (0.60) | TSHRHPGDTHRBS1PR5LMNA | |
| SCHEMBL16547092 | 0.94 | THRB (0.60) | TSHRHPGDTHRBS1PR5LMNA | |
| SCHEMBL16547098 | 0.94 | THRB (0.60) | TSHRHPGDTHRBS1PR5LMNA | |
| SCHEMBL14097956 | 0.93 | THRB (0.51) | TSHRHPGDTHRBTP53SMN1; SMN2 | |
| SCHEMBL21577864 | 0.92 | KCNH2 (0.47) | TSHRHPGDTHRBNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018099883-A1 | POLYMERISABLE LC MEDIUM AND POLYMER FILM WITH FLAT OPTICAL DISPERSION | MERCK PATENT GMBH (DE) | 2018-06-07 | — | — | WO | disclosed |