Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Biperiden. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 7/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 7/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 7/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 5/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | HRH1 | P35367 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.61 |
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.61 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.61 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.61 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biperiden SCHEMBL20229362 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL20211718 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL6775788 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL16449749 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL13898507 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL23697535 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL18281117 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL16449751 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL18281119 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL3909184 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180153870-A1 | BIPERIDEN FOR TREATING CANCER | Universitätsklinikum Hamburg-Eppendorf (DE) | 2018-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180153870-A1 | BIPERIDEN FOR TREATING CANCER | MALT1, CMA1, BECN1 | CHRM1 3866/4885CYP2D6 432/4885CHRM2 4331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.