Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Biperiden. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 7/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 7/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 7/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 5/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | HRH1 | P35367 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.61 |
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.61 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.61 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.61 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biperiden SCHEMBL6775788 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL20229360 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL20211718 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL18281119 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL34957 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL23697535 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL15188450 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL13898506 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL5494381 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 | |
| Biperiden SCHEMBL13898507 | 1.00 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1CHRM3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501519-B2 | Method for producing biperiden IV | ABBOTT GMBH & CO., KG (DE) | 2009-03-10 | — | — | US | disclosed |
| EP-1392667-B1 | METHOD FOR THE PRODUCTION OF BIPERIDIN | FARMACEUTICO S I T SPECIALITA (IT) | 2007-06-27 | — | — | EP | disclosed |
| EP-1389188-B1 | METHOD FOR THE PRODUCTION OF BIPERIDEN II | FARMACEUTICO S I T SPECIALITA (IT) | 2006-06-28 | — | — | EP | disclosed |
| US-7034158-B2 | Method of producing biperiden I | ABBOTT GMBH & CO. KG (DE) | 2006-04-25 | — | — | US | disclosed |
| US-7030247-B2 | Method for the production of biperidin | ABBOTT GMBH & CO. DG (DE) | 2006-04-18 | — | — | US | disclosed |
| EP-1389193-B1 | METHOD FOR PRODUCING BIPERIDEN I | FARMACEUTICO S I T SPECIALITA (IT) | 2005-10-19 | — | — | EP | disclosed |
| EP-1387828-B1 | METHOD FOR PRODUCING BIPERIDEN IV | FARMACEUTICO S I T SPECIALITA (IT) | 2005-10-12 | — | — | EP | disclosed |
| US-20050176963-A1 | Method of producing biperiden I | ABBOTT GMBH (DE) | 2005-08-11 | — | — | US | disclosed |
| US-20040186294-A1 | Method for producing biperiden iv | ABBOTT GMBH & CO. KG (DE) | 2004-09-23 | — | — | US | disclosed |
| US-20040147753-A1 | Method for the production of biperidin | ABBOTT GMBH &O CO. KG (DE) | 2004-07-29 | — | — | US | disclosed |
| EP-1387828-A2 | METHOD FOR PRODUCING BIPERIDEN IV | Abbott GmbH & Co. KG (DE) | 2004-02-11 | — | — | EP | disclosed |
| WO-2002096874-A2 | METHOD FOR PRODUCING BIPERIDEN IV | ABBOTT GMBH & CO. KG (DE) | 2002-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176963-A1 | Method of producing biperiden I | B2M, PPIP5K2, BPGM | CHRM1 393/4885CYP2D6 23/4885CHRM2 381/4885 |
| US-20040147753-A1 | Method for the production of biperidin | B2M, HSPA5, BRD2 | CHRM1 1632/4885CYP2D6 204/4885CHRM2 718/4885 |
| US-20040186294-A1 | Method for producing biperiden iv | EXOC4, EXOC3, EXOC1 | CHRM1 291/4885CYP2D6 1035/4885CHRM2 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.