SCHEMBL202375

SCHEMBL202375

CCOC(=O)Nc1nc2ccccc2n1C(=O)N(C)C

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.58
ALDH1A1 P00352 2/20 0.58
TSHR P16473 4/20 0.53
POLB P06746 3/20 0.52
KDM4E B2RXH2 2/20 0.52
GLA P06280 1/20 0.52
SMN1; SMN2 Q16637 5/20 0.46
RAB9A P51151 4/20 0.46
NPC1 O15118 2/20 0.46
PSMD14 O00487 1/20 0.46
GAA P10253 1/20 0.46
L3MBTL1 Q9Y468 2/20 0.45
LMNA P02545 4/20 0.44
HTT P42858 3/20 0.44
NPSR1 Q6W5P4 2/20 0.44
HIF1A Q16665 1/20 0.44
MEN1 O00255 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL203506 0.87 ALDH1A1 (0.60) KMT2AALDH1A1TSHRPOLBKDM4E
SCHEMBL11826645 0.86 TSHR (0.56) KMT2AALDH1A1TSHRPOLBKDM4E
SCHEMBL203542 0.86 CYP1A2 (0.46) KMT2AALDH1A1TSHRPOLBKDM4E
SCHEMBL14638779 0.84 KMT2A (0.67) KMT2AALDH1A1TSHRPOLBKDM4E
SCHEMBL204271 0.84 ALDH1A1 (0.56) KMT2AALDH1A1TSHRPOLBSMN1; SMN2
SCHEMBL27197724 0.84 TSHR (0.60) KMT2AALDH1A1TSHRPOLBKDM4E
SCHEMBL7102687 0.79 TSHR (0.83) KMT2AALDH1A1TSHRPOLBKDM4E
SCHEMBL11835659 0.79 TSHR (0.49) KMT2AALDH1A1TSHRPOLBKDM4E
SCHEMBL11834636 0.78 ALDH1A1 (0.48) KMT2AALDH1A1TSHRPOLBKDM4E
SCHEMBL11825126 0.78 TSHR (0.47) KMT2AALDH1A1TSHRPOLBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 216 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3746505-B1 COMPOSITION, POLYMER COMPOSITE ARTICLE FORMED THEREWITH, AND METHOD OF PREPARING SAME DOW SILICONES CORP (US) 2024-06-26 EP disclosed
EP-3906245-B1 MULTIFUNCTIONAL ORGANOSILICON COMPOUND AND RELATED METHODS, COMPOUNDS, AND COMPOSITIONS DOW SILICONES CORP (US) 2024-05-29 EP disclosed
US-20240124709-A1 COMPOSITION, POLYMER COMPOSITE ARTICLE FORMED THEREWITH, AND METHOD OF PREPARING SAME DOW GLOBAL TECHNOLOGIES LLC 2024-04-18 US disclosed
EP-3645640-B1 SILICONE-POLYETHER COPOLYMER, METHOD OF PREPARING SAME, AND SEALANT COMPRISING SAME DOW SILICONES CORP (US) 2024-03-06 EP disclosed
US-11884821-B2 Composition, polymer composite article formed therewith, and method of preparing same DOW SILICONES CORPORATION (US) 2024-01-30 US disclosed
US-11820846-B2 Composition, method of preparing copolymer, and methods and end uses thereof DOW SILICONES CORPORATION (US) 2023-11-21 US disclosed
WO-2023215360-A1 SILICONE-POLYETHER COPOLYMER, SEALANTS COMPRISING SAME, AND RELATED METHODS DOW SILICONES CORPORATION (US) 2023-11-09 WO disclosed
US-11807775-B2 Silicone-organic copolymer, sealants comprising same, and related methods DOW SILICONES CORPORATION (US) 2023-11-07 US disclosed
US-11760841-B2 Silicone-polycarbonate copolymer, sealants comprising same, and related methods DOW SILICONES CORPORATION (US) 2023-09-19 US disclosed
EP-3898779-B1 SILICONE-POLYESTER COPOLYMER, SEALANTS COMPRISING SAME, AND RELATED METHODS DOW SILICONES CORP (US) 2023-02-08 EP disclosed
EP-1866366-A1 ORGANOSILOXANE COMPOSITIONS Dow Corning Corporation (US) 2007-12-19 EP disclosed
EP-1866376-A1 ORGANOSILOXANE COMPOSITIONS Dow Corning Corporation (US) 2007-12-19 EP disclosed
WO-2006106359-A2 ORGANOSILOXANE COMPOSITIONS DOW CORNING CORPORATION (US) 2006-10-12 WO disclosed
WO-2006106360-A1 ORGANOSILOXANE COMPOSITIONS DOW CORNING CORPORATION (US) 2006-10-12 WO disclosed
WO-2006106362-A1 ORGANOSILOXANE COMPOSITIONS DOW CORNING CORPORATION (US) 2006-10-12 WO disclosed
WO-2006106361-A1 ORGANOSILOXANE COMPOSITIONS DOW CORNING CORPORATION (US) 2006-10-12 WO disclosed
WO-2006106095-A1 ORGANOSILOXANE COMPOSITIONS DOW CORNING CORPORATION (US) 2006-10-12 WO disclosed
EP-0585587-B1 Fungiresistant polyorganosiloxane composition TOSHIBA SILICONE (JP) 1997-05-21 EP disclosed
US-5378406-A Benzimidazolylcarbamate, pyridyl oxide zinc salt TOSHIBA SILICONE CO., LTD. (JP) 1995-01-03 US disclosed
EP-0585587-A1 Fungiresistant polyorganosiloxane composition TOSHIBA SILICONE CO., LTD. (JP) 1994-03-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11820846-B2 Composition, method of preparing copolymer, and methods and end uses thereof BRS3, OXSR1, OXER1 KMT2A 4700/4885ALDH1A1 3354/4885TSHR 566/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.