Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2958326 | 0.95 | KMT2A (0.46) | KMT2AALDH1A1KDM4EMEN1CYP3A4 | |
| Hydrochloric Acid SCHEMBL28907031 | 0.93 | KMT2A (0.45) | KMT2AALDH1A1KDM4EMEN1CYP3A4 | |
| SCHEMBL28999586 | 0.82 | — | — | |
| SCHEMBL8110294 | 0.82 | HRH3 (0.41) | KMT2AALDH1A1MEN1SMN1; SMN2LMNA | |
| SCHEMBL119860 | 0.82 | HRH3 (0.41) | KMT2AALDH1A1MEN1SMN1; SMN2LMNA | |
| SCHEMBL120015 | 0.80 | PNMT (0.41) | KMT2AALDH1A1KDM4EMEN1SMN1; SMN2 | |
| SCHEMBL8114067 | 0.80 | PNMT (0.41) | KMT2AALDH1A1KDM4EMEN1SMN1; SMN2 | |
| Iodide SCHEMBL7417352 | 0.80 | HRH3 (0.40) | KMT2AALDH1A1MEN1SMN1; SMN2LMNA | |
| SCHEMBL6941412 | 0.78 | PNMT (0.43) | KMT2AALDH1A1KDM4EMEN1SMN1; SMN2 | |
| SCHEMBL8109596 | 0.78 | PNMT (0.43) | KMT2AALDH1A1KDM4EMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10376592-B2 | Stapled acid-sensitive endosome disrupting alginates | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2019-08-13 | — | — | US | claimed |
| US-20180161441-A1 | STAPLED ACID-SENSITIVE ENDOSOME DISRUPTING ALGINATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2018-06-14 | — | — | US | claimed |
| US-10967066-B2 | Stapled acid-sensitive endosome disrupting alginates | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2021-04-06 | — | — | US | disclosed |
| US-20190307889-A1 | STAPLED ACID-SENSITIVE ENDOSOME DISRUPTING ALGINATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-10-10 | — | — | US | disclosed |
| US-10376592-B2 | Stapled acid-sensitive endosome disrupting alginates | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2019-08-13 | — | — | US | disclosed |
| US-20180161441-A1 | STAPLED ACID-SENSITIVE ENDOSOME DISRUPTING ALGINATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180161441-A1 | STAPLED ACID-SENSITIVE ENDOSOME DISRUPTING ALGINATES | ALG1, ALG8, EEA1 | KMT2A 3688/4885ALDH1A1 2942/4885KDM4E 4031/4885 |
| US-20190307889-A1 | STAPLED ACID-SENSITIVE ENDOSOME DISRUPTING ALGINATES | ALG1, ALG8, EEA1 | KMT2A 3688/4885ALDH1A1 2942/4885KDM4E 4031/4885 |
| US-10967066-B2 | Stapled acid-sensitive endosome disrupting alginates | ALG1, ALG8, EEA1 | KMT2A 3688/4885ALDH1A1 2942/4885KDM4E 4031/4885 |
| US-10376592-B2 | Stapled acid-sensitive endosome disrupting alginates | ALG1, ALG8, EEA1 | KMT2A 3688/4885ALDH1A1 2942/4885KDM4E 4031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.