Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HTR6 | P50406 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3695562 | 0.86 | LMNA (0.52) | LMNAMEN1KMT2AKDM4EMAPK1 | |
| SCHEMBL20240708 | 0.85 | LMNA (0.34) | LMNACASP1MEN1ABCC4PKM | |
| SCHEMBL3697693 | 0.84 | LMNA (0.54) | LMNACASP1MEN1ABCC4PKM | |
| SCHEMBL20240766 | 0.84 | GSK3B (0.47) | LMNACASP1MEN1ABCC4PKM | |
| SCHEMBL21815683 | 0.82 | HSD17B10 (0.42) | LMNACASP1MEN1ABCC4PKM | |
| SCHEMBL27696252 | 0.79 | HSD17B10 (0.36) | LMNACASP1MEN1ABCC4PKM | |
| SCHEMBL20240693 | 0.79 | CNR2 (0.43) | LMNACASP1SMN1; SMN2CNR2 | |
| SCHEMBL20242872 | 0.78 | GSK3B (0.40) | LMNACASP1MEN1ABCC4PKM | |
| SCHEMBL3695215 | 0.77 | LMNA (0.40) | LMNACASP1MEN1ABCC4PKM | |
| SCHEMBL20257884 | 0.76 | LMNA (0.36) | LMNACASP1MEN1ABCC4PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018102885-A1 | MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2018-06-14 | — | — | WO | disclosed |
| WO-2018102885-A1 | MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS AND USES THEREOF | BIONOMICS LIMITED (AU) | 2018-06-14 | — | — | WO | disclosed |