Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18957514 | 1.00 | CHRNA7 (0.31) | CHRNA7PIM1PIM3PIM2 | |
| SCHEMBL2385755 | 0.79 | — | — | |
| SCHEMBL5101181 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL31340503 | 0.77 | PIM1 (0.33) | CHRNA7PIM1PIM3PIM2 | |
| Hydrochloric Acid SCHEMBL22118548 | 0.75 | — | — | |
| SCHEMBL23970309 | 0.72 | — | — | |
| SCHEMBL14527947 | 0.72 | MEN1 (0.36) | CHRNA7PIM1PIM3PIM2 | |
| SCHEMBL4739305 | 0.72 | CYP2D6 (0.37) | — | |
| Hydrochloric Acid SCHEMBL31340824 | 0.71 | MEN1 (0.35) | — | |
| SCHEMBL644462 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018103058-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-14 | — | — | WO | disclosed |