⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2385755 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL31340503 | 0.98 | PIM1 (0.33) | — | |
| SCHEMBL14527947 | 0.93 | MEN1 (0.36) | — | |
| Hydrochloric Acid SCHEMBL31340824 | 0.91 | MEN1 (0.35) | — | |
| SCHEMBL1543420 | 0.88 | — | — | |
| SCHEMBL3430377 | 0.88 | — | — | |
| SCHEMBL1306373 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL31340914 | 0.86 | — | — | |
| Trifluoroacetic Acid SCHEMBL28501417 | 0.84 | IRAK4 (0.36) | — | |
| SCHEMBL2384864 | 0.81 | HSD17B10 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115348961-A | Heterocyclic PAD4 inhibitors | 百时美施贵宝公司 | 2022-11-15 | — | — | CN | claimed |
| WO-2018029117-A1 | NEW ATR INHIBITORS FOR THE USE IN CANCER THERAPY | Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) (DE) | 2018-02-15 | — | — | WO | claimed |
| US-20140309192-A1 | MODULATORS OF THE G PROTEIN-COUPLED MAS RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC, | 2014-10-16 | — | — | US | claimed |
| CN-104105691-A | MODULATORS OF THE G PROTEIN-COUPLED MAS RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC | 2014-10-15 | — | — | CN | claimed |
| EP-2776407-A1 | MODULATORS OF THE G PROTEIN-COUPLED MAS RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2014-09-17 | — | — | EP | claimed |
| WO-2013070657-A1 | MODULATORS OF THE G PROTEIN-COUPLED MAS RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2013-05-16 | — | — | WO | claimed |
| US-20080132496-A1 | CARBOXYLIC ACID AMIDES, THE PREPARATION THEREOF, AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2008-06-05 | — | — | US | claimed |
| US-20040220169-A1 | Carboxylic acid amides, the preparation thereof, and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-11-04 | — | — | US | claimed |
| CN-114478539-B | Novel DCLK1 inhibitor and preparation method and application thereof | 中国人民解放军海军军医大学 | 2024-02-02 | — | — | CN | disclosed |
| CN-115348961-A | Heterocyclic PAD4 inhibitors | 百时美施贵宝公司 | 2022-11-15 | — | — | CN | disclosed |
| CN-114478539-A | Novel DCLK1 inhibitor and preparation method and application thereof | 中国人民解放军海军军医大学 | 2022-05-13 | — | — | CN | disclosed |
| CN-111978317-A | Imidazopyridine MNK1/MNK2 kinase inhibitor and preparation method and application thereof | 上海道熵生物科技有限公司 | 2020-11-24 | — | — | CN | disclosed |
| WO-2019152883-A1 | INHIBITORS OF PROTEIN ARGININE DEIMINASES | PADFORWARD LLC (US) | 2019-08-08 | — | — | WO | disclosed |
| WO-2018068295-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
| US-7332509-B2 | Heterocyclic amides, a process for their preparation, compositions comprising them and their use | MERIAL LIMITED (US) | 2008-02-19 | — | — | US | disclosed |
| US-7332509-B2 | Heterocyclic amides, a process for their preparation, compositions comprising them and their use | MERIAL LIMITED (US) | 2008-02-19 | — | — | US | disclosed |
| US-7326791-B2 | Carboxylic acid amides, the preparation thereof, and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO., KG (DE) | 2008-02-05 | — | — | US | disclosed |
| US-20040220169-A1 | Carboxylic acid amides, the preparation thereof, and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-11-04 | — | — | US | disclosed |
| CN-1077110-C | 13-substituted milbemycin 5-oxime derivatives their preparation and their use against insects and other pests | SANKYO CO (JP) | 2002-01-02 | — | — | CN | disclosed |
| CN-1153177-A | 13-substituted milbemycin 5-oxime derivatives their preparation and their use against insects and other pests | SANKYO CO (JP) | 1997-07-02 | — | — | CN | disclosed |