Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.36 |
| ▸ | F2R | P25116 | 2/20 | 0.35 |
| ▸ | DOCK2 | Q92608 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | SNCA | P37840 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14712955 | 0.82 | METAP1 (0.56) | METAP1F2RDOCK2MAPTKDM4E | |
| SCHEMBL19820143 | 0.75 | HDAC2 (0.42) | METAP1MAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL14713024 | 0.73 | MAPT (0.45) | METAP1DOCK2MAPTKDM4EALDH1A1 | |
| SCHEMBL5561570 | 0.69 | CDK4 (0.52) | F2RMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL628777 | 0.69 | CDK4 (0.52) | F2RMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL7905215 | 0.68 | TSHR (0.48) | F2RKDM4EALDH1A1HTTLMNA | |
| SCHEMBL29732385 | 0.68 | TSHR (0.48) | F2RKDM4EALDH1A1HTTLMNA | |
| SCHEMBL1932223 | 0.68 | TSHR (0.48) | F2RKDM4EALDH1A1HTTLMNA | |
| SCHEMBL9187108 | 0.66 | TSHR (0.46) | F2RKDM4EALDH1A1HTTLMNA | |
| SCHEMBL1399132 | 0.66 | CA1 (0.43) | F2RMAPTKDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9994554-B2 | Barbiturate and thiobarbiturate compounds for use in cancer therapy | NUHOPE LLC (US) | 2018-06-12 | — | — | US | disclosed |