Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.41 |
| ▸ | MAPT | P10636 | 13/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6231219 | 0.78 | KMT2A (0.47) | KMT2AMAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL1101098 | 0.74 | ALDH1A1 (0.42) | KMT2AMAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL2680644 | 0.74 | F2 (0.55) | KMT2AMAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL12081774 | 0.72 | MAPT (0.53) | KMT2AMAPTALDH1A1NPSR1MEN1 | |
| SCHEMBL10014431 | 0.71 | MAPT (0.53) | KMT2AMAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL14712892 | 0.70 | MAPT (0.72) | KMT2AMAPTALDH1A1NPSR1MEN1 | |
| SCHEMBL14712900 | 0.69 | MAPT (0.56) | KMT2AMAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL20243760 | 0.68 | KMT2A (0.52) | KMT2AMAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL14713066 | 0.68 | MEN1 (0.64) | KMT2AMAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL14712870 | 0.67 | KMT2A (0.51) | KMT2AMAPTALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9994554-B2 | Barbiturate and thiobarbiturate compounds for use in cancer therapy | NUHOPE LLC (US) | 2018-06-12 | — | — | US | disclosed |