Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 9/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.37 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20246553 | 0.90 | JAK1 (0.37) | JAK2JAK1DDB1CRBN | |
| SCHEMBL20246160 | 0.87 | JAK2 (0.42) | SMN1; SMN2JAK2JAK1ACKR3 | |
| SCHEMBL20246546 | 0.85 | SMN1; SMN2 (0.35) | SMN1; SMN2JAK2JAK1ACKR3 | |
| SCHEMBL20246288 | 0.84 | JAK1 (0.45) | SMN1; SMN2JAK2JAK1ACKR3 | |
| SCHEMBL20246362 | 0.84 | SMN1; SMN2 (0.38) | SMN1; SMN2JAK2JAK1ACKR3 | |
| SCHEMBL20246379 | 0.84 | ACKR3 (0.47) | JAK2JAK1ACKR3 | |
| SCHEMBL16623571 | 0.83 | JAK1 (0.34) | SMN1; SMN2JAK2JAK1 | |
| SCHEMBL20246137 | 0.83 | JAK2 (0.48) | SMN1; SMN2JAK2JAK1ACKR3 | |
| SCHEMBL20246134 | 0.83 | SMN1; SMN2 (0.35) | SMN1; SMN2ACKR3 | |
| SCHEMBL17849240 | 0.83 | JAK1 (0.43) | SMN1; SMN2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2976340-B1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-06-13 | — | — | EP | disclosed |