Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 8/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16623602 | 0.88 | JAK1 (0.37) | JAK1EPHX1RAB9AEGFRJAK2 | |
| SCHEMBL20246056 | 0.87 | HCAR3 (0.40) | JAK1SMN1; SMN2EPHX2EPHX1RAB9A | |
| SCHEMBL20246042 | 0.87 | RAB9A (0.46) | JAK1SMN1; SMN2EPHX1RAB9AEGFR | |
| SCHEMBL16623571 | 0.86 | JAK1 (0.34) | JAK1SMN1; SMN2EPHX2EPHX1RAB9A | |
| SCHEMBL20246309 | 0.85 | EPHX1 (0.47) | JAK1EPHX2EPHX1RAB9AMAPT | |
| SCHEMBL20246326 | 0.84 | LMNA (0.46) | JAK1SMN1; SMN2EPHX2EPHX1MAPT | |
| SCHEMBL20246553 | 0.84 | JAK1 (0.37) | JAK1EPHX2EPHX1RAB9AMAPT | |
| SCHEMBL20246179 | 0.84 | BRD4 (0.44) | JAK1EPHX2JAK2HPGDALDH1A1 | |
| SCHEMBL16623521 | 0.84 | JAK1 (0.39) | JAK1RAB9AMAPTJAK2KDM4E | |
| SCHEMBL20246136 | 0.83 | SMN1; SMN2 (0.40) | JAK1SMN1; SMN2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |