Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20668109 | 0.82 | KDM4E (0.51) | TP53HPGDNPSR1ALDH1A1KDM4E | |
| SCHEMBL18703107 | 0.79 | ALDH1A1 (0.44) | TP53HPGDNPSR1ALDH1A1KDM4E | |
| SCHEMBL29503001 | 0.74 | CA12 (0.43) | TP53HPGDNPSR1ALDH1A1KDM4E | |
| SCHEMBL18702637 | 0.74 | CA12 (0.43) | TP53HPGDNPSR1ALDH1A1KDM4E | |
| SCHEMBL13891958 | 0.73 | ALDH1A1 (0.43) | TP53HPGDALDH1A1KDM4ETSHR | |
| SCHEMBL15503756 | 0.70 | TP53 (0.75) | TP53MEN1KMT2AMAPTLMNA | |
| SCHEMBL13475475 | 0.68 | GAA (0.56) | HPGDNPSR1ALDH1A1KDM4ETSHR | |
| SCHEMBL10114020 | 0.68 | HPGD (0.46) | TP53HPGDNPSR1ALDH1A1KDM4E | |
| SCHEMBL718444 | 0.67 | ABCB1 (0.44) | TP53HPGDALDH1A1KDM4ETSHR | |
| SCHEMBL27637915 | 0.66 | CA12 (0.57) | HPGDALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892525-B1 | METHODS OF TREATING MUSCULAR DYSTROPHY | UNIV NEVADA RENO (US) | 2018-06-13 | — | — | EP | disclosed |