Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20247692 | 0.84 | GAA (0.48) | GAANFKB1NFKB2RELABTK | |
| SCHEMBL19082698 | 0.81 | GAA (0.46) | GAANFKB1NFKB2RELABTK | |
| SCHEMBL3621203 | 0.77 | GAA (0.54) | GAANFKB1NFKB2RELABTK | |
| SCHEMBL2771992 | 0.77 | GAA (0.54) | GAANFKB1NFKB2RELABTK | |
| SCHEMBL2770955 | 0.76 | GAA (0.49) | GAANFKB1NFKB2RELABTK | |
| SCHEMBL2770869 | 0.76 | GAA (0.49) | GAANFKB1NFKB2RELABTK | |
| SCHEMBL19082697 | 0.75 | GAA (0.46) | GAANFKB1NFKB2RELABTK | |
| SCHEMBL21014514 | 0.73 | CTSK (0.48) | GAANFKB1NFKB2RELABTK | |
| SCHEMBL17309418 | 0.72 | GAA (0.46) | GAANFKB1NFKB2RELABTK | |
| SCHEMBL24818982 | 0.71 | GAA (0.51) | GAANFKB1NFKB2RELABTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148963-B1 | 1-(CYCLOPENT-2-EN-1-YL)-3-(2-HYDROXY-3-(ARYLSULFONYL)PHENYL)UREA DERIVATIVES AS CXCR2 INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-06-13 | — | — | EP | disclosed |