Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28035570 | 0.80 | CYP2D6 (0.54) | CYP2D6CYP2C19CYP1A2TDP1TSHR | |
| SCHEMBL9476209 | 0.79 | CYP2D6 (0.49) | CYP2D6CYP2C19CYP1A2TDP1TSHR | |
| SCHEMBL29199324 | 0.78 | TDP1 (0.64) | CYP2D6CYP2C19CYP1A2TDP1TSHR | |
| Hydrogen Peroxide SCHEMBL28474133 | 0.78 | TDP1 (0.64) | CYP2D6CYP2C19CYP1A2TDP1TSHR | |
| SCHEMBL260960 | 0.78 | TDP1 (0.64) | CYP2D6CYP2C19CYP1A2TDP1TSHR | |
| SCHEMBL1786261 | 0.78 | TSHR (0.59) | CYP2D6CYP2C19CYP1A2TDP1TSHR | |
| SCHEMBL1953844 | 0.78 | TSHR (0.59) | CYP2D6CYP2C19CYP1A2TDP1TSHR | |
| Hydrogen Peroxide SCHEMBL28425777 | 0.78 | TDP1 (0.64) | CYP2D6CYP2C19CYP1A2TDP1TSHR | |
| SCHEMBL263461 | 0.77 | TDP1 (0.58) | CYP2D6CYP2C19CYP1A2TDP1TSHR | |
| Hydrochloric Acid SCHEMBL23276979 | 0.76 | TDP1 (0.62) | CYP2D6CYP2C19CYP1A2TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088872-B2 | Procatalyst composition including silyl ester internal donor and method | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-01-03 | — | — | US | claimed |
| US-20100130709-A1 | Procatalyst Composition Including Silyl Ester Internal Donor and Method | W. R. GRACE & CO.-CONN. | 2010-05-27 | — | — | US | claimed |
| EP-2350143-B1 | PROCATALYST COMPOSITION MULTIPLE INTERNAL DONOR HAVING SILYL ESTER AND METHOD | GRACE W R & CO (US) | 2016-02-17 | — | — | EP | disclosed |
| EP-2350144-B1 | PROCATALYST COMPOSITION INCLUDING SILYL ESTER INTERNAL DONOR AND METHOD | GRACE W R & CO (US) | 2015-07-15 | — | — | EP | disclosed |
| US-8222357-B2 | Procatalyst composition with multiple internal donor having silyl ester and method | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY LLC (US) | 2012-07-17 | — | — | US | disclosed |
| US-8088872-B2 | Procatalyst composition including silyl ester internal donor and method | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-01-03 | — | — | US | disclosed |
| EP-2350144-A1 | PROCATALYST COMPOSITION INCLUDING SILYL ESTER INTERNAL DONOR AND METHOD | Dow Global Technologies LLC (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010065361-A1 | PROCATALYST COMPOSITION INCLUDING SILYL ESTER INTERNAL DONOR AND METHOD | DOW GLOBAL TECHNOLOGIES INC. (US) | 2010-06-10 | — | — | WO | disclosed |
| US-20100130710-A1 | Procatalyst Composition with Multiple Internal Donor Having Silyl Ester and Method | W. R. GRACE & CO.-CONN. | 2010-05-27 | — | — | US | disclosed |
| US-20100130709-A1 | Procatalyst Composition Including Silyl Ester Internal Donor and Method | W. R. GRACE & CO.-CONN. | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130709-A1 | Procatalyst Composition Including Silyl Ester Internal Donor and Method | GNE, NANS, ELANE | CYP2D6 1662/4885CYP2C19 2907/4885CYP1A2 570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.