Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 9/20 | 0.43 |
| ▸ | KDM5C | P41229 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | PAICS | P22234 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20038507 | 0.81 | CXCR4 (0.44) | CXCR4KDM5CKDM4CSIGMAR1MEN1 | |
| SCHEMBL13764446 | 0.78 | CXCR4 (0.45) | CXCR4KDM5CKDM4CSIGMAR1MEN1 | |
| SCHEMBL20255230 | 0.77 | CYP2C19 (0.42) | MEN1KMT2ATDP1HRH3LMNA | |
| SCHEMBL20037553 | 0.77 | CXCR4 (0.41) | CXCR4KDM5CKDM4CSIGMAR1MEN1 | |
| SCHEMBL20249430 | 0.76 | CXCR4 (0.40) | CXCR4KDM5CKDM4CSIGMAR1MEN1 | |
| SCHEMBL18291020 | 0.75 | CXCR4 (0.51) | CXCR4SIGMAR1MEN1KMT2ACHRM2 | |
| SCHEMBL3148862 | 0.74 | CXCR4 (0.50) | CXCR4KDM5CKDM4CSIGMAR1MEN1 | |
| SCHEMBL32667730 | 0.73 | CYP11B1 (0.51) | CXCR4KDM5CKDM4CSIGMAR1LMNA | |
| SCHEMBL20037955 | 0.72 | CXCR4 (0.46) | CXCR4KDM5CKDM4CSIGMAR1MEN1 | |
| SCHEMBL20160684 | 0.71 | CXCR4 (0.49) | CXCR4KDM5CKDM4CSIGMAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | TEIJIN PHARMA LIMITED (JP) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | CDK4, CDK6, CDK16 | CXCR4 1021/4885KDM5C 1003/4885KDM4C 917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.