Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2026520 | 1.00 | HDAC1 (0.30) | HDAC1HDAC2HDAC6 | |
| SCHEMBL2027234 | 0.86 | — | — | |
| SCHEMBL2027235 | 0.86 | — | — | |
| SCHEMBL2026512 | 0.81 | — | — | |
| SCHEMBL17610528 | 0.79 | USP30 (0.31) | — | |
| SCHEMBL8238574 | 0.76 | HDAC6 (0.36) | HDAC1HDAC2HDAC6 | |
| SCHEMBL873988 | 0.75 | — | — | |
| SCHEMBL873989 | 0.75 | — | — | |
| SCHEMBL16447368 | 0.74 | — | — | |
| SCHEMBL4973665 | 0.74 | CTSK (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516434-A1 | FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011079051-A1 | FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-06-30 | — | — | WO | disclosed |