Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20267398 | 0.84 | KMT2A (0.64) | KMT2AMEN1POLBUSP2ALDH1A1 | |
| SCHEMBL17560638 | 0.84 | HRH3 (0.45) | SIGMAR1KMT2AMEN1OPRD1 | |
| SCHEMBL11476095 | 0.83 | KMT2A (0.67) | KMT2AMEN1POLBUSP2ALDH1A1 | |
| SCHEMBL11236018 | 0.83 | KMT2A (0.50) | SIGMAR1KMT2AMEN1USP2ALDH1A1 | |
| SCHEMBL22031536 | 0.80 | SIGMAR1 (0.40) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL20267172 | 0.80 | KMT2A (0.53) | KMT2AMEN1POLBTSHRCASP3 | |
| SCHEMBL20267432 | 0.80 | KMT2A (0.68) | KMT2AMEN1POLBTSHRCASP3 | |
| SCHEMBL27876101 | 0.79 | KMT2A (0.51) | KMT2AMEN1POLBALDH1A1HSD17B10 | |
| SCHEMBL7958970 | 0.79 | SIGMAR1 (0.42) | SIGMAR1KMT2AMEN1CASP3SENP7 | |
| SCHEMBL28214603 | 0.78 | RXFP1 (0.47) | SIGMAR1KMT2AMEN1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551633-A1 | SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2019-10-16 | — | — | EP | claimed |
| WO-2018108230-A1 | SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2018-06-21 | — | — | WO | claimed |
| WO-2023081452-A1 | SMALL-MOLECULE DEGRADERS OF CDK8 AND CDK19 | UNIVERSITY OF SOUTH CAROLINA (US) | 2023-05-11 | — | — | WO | disclosed |
| CN-104379578-B | Carbamate compounds and its preparation and application | 阿比德治疗公司 | 2017-06-09 | — | — | CN | disclosed |