Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.54 |
| ▸ | GBA1 | P04062 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | USP1 | O94782 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14475219 | 0.89 | PDE5A (0.60) | PDE5AGBA1POLBHPGDKDM4E | |
| SCHEMBL14475092 | 0.86 | PDE5A (0.54) | PDE5AGBA1POLBHPGDKDM4E | |
| SCHEMBL14475031 | 0.84 | PDE5A (0.53) | PDE5AGBA1POLBHPGDKDM4E | |
| SCHEMBL14727823 | 0.83 | PDE5A (0.62) | PDE5AGBA1POLBHPGDKDM4E | |
| SCHEMBL14474100 | 0.82 | PDE5A (0.61) | PDE5AGBA1POLBHPGDKDM4E | |
| SCHEMBL14475213 | 0.80 | CYP1A2 (0.59) | PDE5AGBA1POLBHPGDKDM4E | |
| SCHEMBL2155510 | 0.79 | CCNE2 (0.58) | PDE5AGBA1POLBHPGDKDM4E | |
| SCHEMBL14474979 | 0.79 | MEN1 (0.57) | PDE5AGBA1POLBHPGDKDM4E | |
| SCHEMBL14727599 | 0.79 | PDE5A (0.57) | PDE5AGBA1POLBHPGDCYP1A2 | |
| SCHEMBL16183681 | 0.79 | PDE5A (0.68) | PDE5AGBA1POLBKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3056207-B1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMA CO LTD (JP) | 2018-06-20 | — | — | EP | disclosed |