Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8414862 | 0.78 | CNR1 (0.48) | CNR1CNR2TP53SMN1; SMN2NPC1 | |
| SCHEMBL26070967 | 0.74 | CNR1 (0.36) | CNR1CNR2GABRA1GABRG2GABRB3 | |
| SCHEMBL18006364 | 0.73 | CYP11B1 (0.36) | CNR1CNR2GABRA1GABRG2GABRB3 | |
| SCHEMBL14474101 | 0.71 | CYP1A2 (0.51) | KDM4EALDH1A1MAPTHIF1A | |
| SCHEMBL30174489 | 0.65 | CNR2 (0.41) | CNR1CNR2ELANEKDM4E | |
| SCHEMBL14892448 | 0.63 | KDM4E (0.41) | CNR1CNR2SMN1; SMN2ELANEKDM4E | |
| SCHEMBL30174419 | 0.63 | AKR1B1 (0.39) | CNR1CNR2NPC1RAB9AMAPT | |
| SCHEMBL17910321 | 0.63 | KDM4E (0.41) | CNR1CNR2PRMT5KDM4E | |
| SCHEMBL5009531 | 0.63 | L3MBTL1 (0.45) | CNR1CNR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL29585194 | 0.63 | KDM4E (0.41) | CNR1CNR2PRMT5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3056207-B1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMA CO LTD (JP) | 2018-06-20 | — | — | EP | disclosed |