Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 14/20 | 0.56 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20280178 | 0.81 | MAPT (0.59) | KCNH2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL20280048 | 0.81 | KCNH2 (0.59) | KCNH2RIOK2NPC1RAB9AMEN1 | |
| SCHEMBL11759552 | 0.79 | KCNH2 (0.66) | KCNH2RIOK2MEN1KMT2AMAPT | |
| SCHEMBL11759545 | 0.79 | KCNH2 (0.66) | KCNH2RIOK2MEN1KMT2AMAPT | |
| SCHEMBL20280214 | 0.76 | KCNH2 (0.50) | KCNH2RIOK2NPC1RAB9AMEN1 | |
| SCHEMBL11414575 | 0.75 | KCNH2 (0.62) | KCNH2RIOK2NPC1RAB9AMEN1 | |
| SCHEMBL11414578 | 0.75 | KCNH2 (0.62) | KCNH2RIOK2NPC1RAB9AMEN1 | |
| SCHEMBL20280331 | 0.75 | KCNH2 (0.59) | KCNH2RIOK2NPC1RAB9AMEN1 | |
| SCHEMBL20280314 | 0.74 | KCNH2 (0.58) | KCNH2RIOK2NPC1RAB9AMEN1 | |
| SCHEMBL4343598 | 0.73 | KCNH2 (0.64) | KCNH2RIOK2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3347001-B1 | AZOPHENOLS AS ERG ONCOGENE INHIBITORS | HENRY M JACKSON FOUND ADVANCEMENT MILITARY MEDICINE INC (US) | 2023-07-26 | — | — | EP | disclosed |
| US-10238639-B2 | Azophenols as ERG oncogene inhibitors | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2019-03-26 | — | — | US | disclosed |
| US-20180169074-A1 | Azophenols as ERG Oncogene Inhibitors | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2018-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169074-A1 | Azophenols as ERG Oncogene Inhibitors | ERG, ESR1, CBX2 | KCNH2 3350/4885RIOK2 2127/4885NPC1 3799/4885 |
| US-10238639-B2 | Azophenols as ERG oncogene inhibitors | ERG, ESR1, CBX2 | KCNH2 3350/4885RIOK2 2127/4885NPC1 3799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.