Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16907747 | 1.00 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2TSHRUSP2CYP2A13 | |
| SCHEMBL22179798 | 0.88 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2CYP2A13L3MBTL1L3MBTL3 | |
| SCHEMBL26820276 | 0.88 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2CYP2A13L3MBTL1L3MBTL3 | |
| SCHEMBL26820274 | 0.88 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2CYP2A13L3MBTL1L3MBTL3 | |
| SCHEMBL14355430 | 0.85 | ALDH1A1 (0.54) | ALDH1A1TSHRUSP2HRH3 | |
| SCHEMBL23517478 | 0.83 | ALDH1A1 (0.49) | ALDH1A1TSHRUSP2L3MBTL1L3MBTL3 | |
| SCHEMBL16566607 | 0.83 | ALDH1A1 (0.49) | ALDH1A1TSHRUSP2L3MBTL1L3MBTL3 | |
| SCHEMBL15468146 | 0.81 | ALDH1A1 (0.47) | ALDH1A1TSHRUSP2L3MBTL1L3MBTL3 | |
| SCHEMBL12716769 | 0.81 | CYP2A13 (0.46) | ALDH1A1SMN1; SMN2CYP2A13L3MBTL1L3MBTL3 | |
| SCHEMBL8378166 | 0.81 | CYP2A13 (0.46) | ALDH1A1SMN1; SMN2CYP2A13L3MBTL1L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115879-A1 | PYRROLIDINE DERIVATIVES AND METHODS OF USE | GENENTECH, INC. (US) | 2022-06-02 | — | — | WO | disclosed |
| US-20180169094-A1 | PYRIMIDINE PYRAZOLYL DERIVATIVES AND THEIR USE AS IRAK INHIBITORS | MERCK PATENT GMBH (DE) | 2018-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169094-A1 | PYRIMIDINE PYRAZOLYL DERIVATIVES AND THEIR USE AS IRAK INHIBITORS | IRAK2, IRAK3, IRAK1 | ALDH1A1 1540/4885SMN1; SMN2 3790/4885TSHR 2324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.