Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.38 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.38 |
| ▸ | CHI3L2 | Q15782 | 1/20 | 0.38 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23046573 | 0.83 | GRM4 (0.46) | GRM4CHRM4GRM1ROCK2ROCK1 | |
| SCHEMBL18136223 | 0.81 | GRM1 (0.48) | GRM4CHRM4GRM1HRH3CHI3L1 | |
| SCHEMBL20283136 | 0.81 | HSD11B1 (0.48) | GRM4HRH4KCNH2TRPV1 | |
| SCHEMBL18133860 | 0.77 | GRM1 (0.45) | GRM4CHRM4GRM1HRH3CHI3L1 | |
| SCHEMBL29414908 | 0.77 | GRM1 (0.45) | GRM4CHRM4GRM1HRH3CHI3L1 | |
| SCHEMBL19116107 | 0.77 | GRM1 (0.45) | GRM4CHRM4GRM1HRH3CHI3L1 | |
| SCHEMBL19115704 | 0.77 | GRM1 (0.45) | GRM4CHRM4GRM1HRH3CHI3L1 | |
| SCHEMBL22210095 | 0.75 | GRM1 (0.43) | GRM4CHRM4GRM1HRH3CHI3L1 | |
| SCHEMBL20283138 | 0.75 | HRH4 (0.40) | HRH3HRH4KCNH2 | |
| SCHEMBL31595778 | 0.74 | GRM1 (0.48) | GRM4CHRM4GRM1HRH3CHI3L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018112312-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2018-06-21 | — | — | WO | disclosed |