Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19604915 | 0.81 | HRH3 (0.45) | MCHR1HRH4GPR119HRH3PDE10A | |
| SCHEMBL12683431 | 0.81 | CNR2 (0.46) | GRM4CNR2GPR119PDE10AHTR1A | |
| SCHEMBL23046561 | 0.80 | GRM1 (0.44) | MCHR1HRH4GPR119HRH3KCNH2 | |
| SCHEMBL22129422 | 0.77 | PDE10A (0.50) | GRM4MCHR1CNR2GPR119PDE10A | |
| SCHEMBL22153203 | 0.77 | PDE10A (0.46) | GRM4CNR2GPR119PDE10AHTR1A | |
| SCHEMBL20283140 | 0.76 | KCNH2 (0.41) | MCHR1CNR2HRH4HRH3KCNH2 | |
| SCHEMBL23775243 | 0.76 | HRH4 (0.50) | GRM4HRH4GPR119HRH3PANK3 | |
| SCHEMBL21262207 | 0.75 | DRD4 (0.49) | GRM4CNR2GPR119PDE10AHTR1A | |
| SCHEMBL22569545 | 0.75 | DRD4 (0.55) | CNR2HRH4GPR119PDE10AHTR1A | |
| SCHEMBL26581344 | 0.75 | ACACB (0.51) | HRH4GPR119HRH3PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10934276-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2021-03-02 | — | — | US | disclosed |
| WO-2018112312-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2018-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934276-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | CHRM4, CHRM2, CHRM3 | GRM4 27/4885MCHR1 115/4885CNR2 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.