Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 14/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23046563 | 0.83 | GRM4 (0.44) | GRM4HRH4SLC6A9 | |
| SCHEMBL25105773 | 0.74 | HRH4 (0.48) | GRM4HRH4 | |
| SCHEMBL24467748 | 0.73 | HRH4 (0.47) | HRH4HRH3SLC6A9 | |
| SCHEMBL20283141 | 0.73 | CHRM2 (0.39) | HRH4HRH3SLC6A9 | |
| SCHEMBL81467 | 0.71 | HRH4 (0.57) | HRH4HRH3 | |
| SCHEMBL603450 | 0.71 | HRH4 (0.82) | HRH4HRH3 | |
| SCHEMBL24467773 | 0.70 | HRH4 (0.47) | HRH4HRH3SLC6A9 | |
| SCHEMBL19604915 | 0.70 | HRH3 (0.45) | HRH4HRH3KCNH2 | |
| SCHEMBL29631771 | 0.70 | HRH4 (0.47) | HRH4HRH3SLC6A9 | |
| SCHEMBL21831103 | 0.70 | NOTUM (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018112312-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2018-06-21 | — | — | WO | disclosed |