Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20283410 | 0.87 | USP2 (0.43) | USP2SMN1; SMN2ESR2RIPK1NR1H2 | |
| SCHEMBL30850027 | 0.87 | USP2 (0.43) | USP2SMN1; SMN2ESR2RIPK1NR1H2 | |
| SCHEMBL22743890 | 0.83 | CKS1B (0.44) | USP2SMN1; SMN2ESR2MEN1KMT2A | |
| SCHEMBL30098007 | 0.81 | ESR2 (0.50) | USP2SMN1; SMN2ABHD6ESR2POLB | |
| SCHEMBL2891547 | 0.81 | ESR2 (0.50) | USP2SMN1; SMN2ABHD6ESR2POLB | |
| SCHEMBL28627169 | 0.81 | ABHD6 (0.40) | ABHD6POLBRIPK1MEN1KMT2A | |
| SCHEMBL30419519 | 0.80 | ABHD6 (0.63) | ABHD6ESR2POLBMEN1KMT2A | |
| SCHEMBL868119 | 0.80 | ABHD6 (0.63) | ABHD6ESR2POLBMEN1KMT2A | |
| SCHEMBL20281224 | 0.80 | POLB (0.48) | USP2SMN1; SMN2ESR2POLBNR1H2 | |
| SCHEMBL30850017 | 0.79 | NR1H2 (0.46) | ABHD6ESR2POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118206566-A | Hydroxypyridooxazepine as NRF2 activator | 葛兰素史密斯克莱知识产权发展有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-113474349-B | Hydroxypyridooxazepine as NRF2 activator | 葛兰素史密斯克莱知识产权发展有限公司 | 2024-03-01 | — | — | CN | disclosed |
| EP-3555082-B1 | ETHER LINKED TRIAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2022-01-26 | — | — | EP | disclosed |
| WO-2020241853-A1 | BENZOTRIAZOLE DERIVATIVE | 宇部興産株式会社 | 2020-12-03 | — | — | WO | disclosed |
| WO-2018109649-A1 | ETHER LINKED TRIAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-06-21 | — | — | WO | disclosed |