Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.67 |
| ▸ | BRD2 | P25440 | 20/20 | 0.67 |
| ▸ | BRD3 | Q15059 | 19/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.55 |
| ▸ | TAF1 | P21675 | 1/20 | 0.55 |
| ▸ | EP300 | Q09472 | 1/20 | 0.55 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.55 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.55 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.55 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.55 |
| ▸ | BRWD1 | Q9NSI6 | 1/20 | 0.55 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20288506 | 0.92 | BRD4 (0.75) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL23467417 | 0.89 | BRD4 (0.75) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL26487289 | 0.89 | BRD4 (0.64) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL20288468 | 0.88 | BRD4 (0.67) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL20270832 | 0.85 | BRD4 (0.84) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL20288504 | 0.83 | BRD4 (0.80) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL26487532 | 0.83 | BRD4 (0.80) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL20288798 | 0.83 | BRD2 (0.66) | BRD4BRD2BRD3 | |
| SCHEMBL20288542 | 0.82 | BRD2 (0.67) | BRD4BRD2BRD3 | |
| SCHEMBL20270401 | 0.82 | BRD4 (0.76) | BRD4BRD2BRD3CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018111805-A1 | TETRAHYDROQUINOLINE-BASED BROMODOMAIN INHIBITORS | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2018-06-21 | — | — | WO | disclosed |