Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 2/20 | 1.00 |
| ▸ | DYRK1A | Q13627 | 17/20 | 0.60 |
| ▸ | CDC7 | O00311 | 3/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | PIM1 | P11309 | 2/20 | 0.54 |
| ▸ | PRKACA | P17612 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 2/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12281648 | 0.84 | DYRK1B (0.73) | DYRK1BDYRK1ACDC7GSK3BROCK2 | |
| SCHEMBL30233270 | 0.84 | DYRK1B (0.73) | DYRK1BDYRK1ACDC7GSK3BROCK2 | |
| SCHEMBL20292820 | 0.83 | DYRK1B (0.71) | DYRK1BDYRK1ACDC7GSK3BROCK2 | |
| SCHEMBL20292912 | 0.82 | DYRK1B (0.70) | DYRK1BDYRK1ACDC7GSK3BROCK2 | |
| SCHEMBL26174558 | 0.82 | DYRK1B (0.69) | DYRK1BDYRK1ACDC7GSK3BROCK2 | |
| SCHEMBL20318990 | 0.81 | DYRK1B (0.68) | DYRK1BDYRK1ACDK2CDK9CCNT1 | |
| SCHEMBL20292748 | 0.81 | DYRK1B (0.68) | DYRK1BDYRK1ACDC7GSK3BROCK2 | |
| SCHEMBL20292991 | 0.81 | DYRK1B (0.67) | DYRK1BDYRK1ACDC7GSK3BROCK2 | |
| SCHEMBL8939833 | 0.79 | CDC7 (0.67) | DYRK1BDYRK1ACDC7GSK3BROCK2 | |
| SCHEMBL31006512 | 0.78 | DYRK1A (0.66) | DYRK1BDYRK1AGSK3BCDK9CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10577365-B2 | Derivatives of quinoline as inhibitors of DYRK1A and/or DYRK1B kinases | FELICITEX THERAPEUTICS, INC. (US) | 2020-03-03 | — | — | US | claimed |
| EP-3558321-A1 | DERIVATIVES OF QUINOLINES AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | Felicitex Therapeutics, Inc. (US) | 2019-10-30 | — | — | EP | claimed |
| WO-2018119039-A1 | DERIVATIVES OF QUINOLINES AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | FELICITEX THERAPEUTICS, INC. (US) | 2018-06-28 | — | — | WO | claimed |
| US-20180179199-A1 | DERIVATIVES OF QUINOLINE AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | FELICITEX THERAPEUTICS, INC. (US) | 2018-06-28 | — | — | US | claimed |
| EP-4183786-A1 | DERIVATIVES OF QUINOLINES AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | Felicitex Therapeutics, Inc. (US) | 2023-05-24 | — | — | EP | disclosed |
| EP-4183786-A1 | DERIVATIVES OF QUINOLINES AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | Felicitex Therapeutics, Inc. (US) | 2023-05-24 | — | — | EP | disclosed |
| EP-3558321-B1 | DERIVATIVES OF QUINOLINES AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | FELICITEX THERAPEUTICS INC (US) | 2023-02-01 | — | — | EP | disclosed |
| EP-3558321-B1 | DERIVATIVES OF QUINOLINES AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | FELICITEX THERAPEUTICS INC (US) | 2023-02-01 | — | — | EP | disclosed |
| US-10577365-B2 | Derivatives of quinoline as inhibitors of DYRK1A and/or DYRK1B kinases | FELICITEX THERAPEUTICS, INC. (US) | 2020-03-03 | — | — | US | disclosed |
| US-10577365-B2 | Derivatives of quinoline as inhibitors of DYRK1A and/or DYRK1B kinases | FELICITEX THERAPEUTICS, INC. (US) | 2020-03-03 | — | — | US | disclosed |
| EP-3558321-A1 | DERIVATIVES OF QUINOLINES AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | Felicitex Therapeutics, Inc. (US) | 2019-10-30 | — | — | EP | disclosed |
| US-20180179199-A1 | DERIVATIVES OF QUINOLINE AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | FELICITEX THERAPEUTICS, INC. (US) | 2018-06-28 | — | — | US | disclosed |
| US-20180179199-A1 | DERIVATIVES OF QUINOLINE AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | FELICITEX THERAPEUTICS, INC. (US) | 2018-06-28 | — | — | US | disclosed |
| WO-2018119039-A1 | DERIVATIVES OF QUINOLINES AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | FELICITEX THERAPEUTICS, INC. (US) | 2018-06-28 | — | — | WO | disclosed |
| US-20180179199-A1 | DERIVATIVES OF QUINOLINE AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | FELICITEX THERAPEUTICS, INC. (US) | 2018-06-28 | — | — | US | disclosed |
| WO-2018119039-A1 | DERIVATIVES OF QUINOLINES AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | FELICITEX THERAPEUTICS, INC. (US) | 2018-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10577365-B2 | Derivatives of quinoline as inhibitors of DYRK1A and/or DYRK1B kinases | DYRK1A, DYRK1B, DYRK2 | DYRK1B 2/4885DYRK1A 1/4885CDC7 460/4885 |
| US-20180179199-A1 | DERIVATIVES OF QUINOLINE AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | DYRK1A, DYRK1B, DYRK2 | DYRK1B 2/4885DYRK1A 1/4885CDC7 460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.