⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20293784 | 1.00 | — | — | |
| SCHEMBL21225251 | 0.84 | — | — | |
| SCHEMBL20556279 | 0.84 | — | — | |
| SCHEMBL22711284 | 0.84 | CTSS (0.41) | — | |
| SCHEMBL19560808 | 0.84 | CTSS (0.41) | — | |
| SCHEMBL1863959 | 0.81 | BTN3A1 (0.33) | — | |
| SCHEMBL17357790 | 0.78 | CTSS (0.50) | — | |
| SCHEMBL16933947 | 0.78 | — | — | |
| SCHEMBL23805208 | 0.78 | GRN (0.41) | — | |
| SCHEMBL23805209 | 0.78 | GRN (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210155632-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC (US) | 2021-05-27 | — | — | US | disclosed |
| EP-2951182-B1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC (US) | 2020-03-18 | — | — | EP | disclosed |
| US-20180244680-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | NAUREX, INC. | 2018-08-30 | — | — | US | disclosed |
| US-20180215767-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | NAUREX, INC. | 2018-08-02 | — | — | US | disclosed |
| US-20180179218-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | NAUREX, INC. | 2018-06-28 | — | — | US | disclosed |