Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 19/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | GSK3A | P49840 | 1/20 | 0.67 |
| ▸ | GSK3B | P49841 | 1/20 | 0.67 |
| ▸ | PDE5A | O76074 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20299040 | 0.82 | HPGD (0.76) | ABCG2ALDH1A1LMNAPOLBHPGD | |
| SCHEMBL20299204 | 0.81 | ABCG2 (0.72) | ABCG2 | |
| SCHEMBL1083761 | 0.81 | HPGD (1.00) | ABCG2ALDH1A1LMNAPOLBHPGD | |
| SCHEMBL20299226 | 0.80 | HPGD (0.80) | ABCG2ALDH1A1LMNAPOLBHPGD | |
| SCHEMBL415388 | 0.79 | ABCG2 (0.64) | ABCG2 | |
| SCHEMBL20547707 | 0.78 | HPGD (0.80) | ABCG2ALDH1A1LMNAPOLBHPGD | |
| SCHEMBL7438289 | 0.77 | PDE5A (0.79) | ABCG2ALDH1A1POLBPDE5A | |
| SCHEMBL3587306 | 0.74 | ABCG2 (0.62) | ABCG2POLB | |
| SCHEMBL14726136 | 0.74 | ABCG2 (0.72) | ABCG2PDE5A | |
| SCHEMBL3585835 | 0.73 | ABCG2 (0.70) | ABCG2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558964-B1 | 4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2022-05-04 | — | — | EP | disclosed |
| EP-3558964-B1 | 4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2022-05-04 | — | — | EP | disclosed |
| US-10889560-B2 | 4-amino-2-pyrido-bicyclic pyrimidines and use thereof as topoisomerase II inhibitors | UNIVERSITÀ DEGLI STUDI DI PADOVA (IT) | 2021-01-12 | — | — | US | disclosed |
| US-10889560-B2 | 4-amino-2-pyrido-bicyclic pyrimidines and use thereof as topoisomerase II inhibitors | UNIVERSITÀ DEGLI STUDI DI PADOVA (IT) | 2021-01-12 | — | — | US | disclosed |
| EP-3558964-A1 | 4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS | Fondazione Istituto Italiano di Tecnologia (IT) | 2019-10-30 | — | — | EP | disclosed |
| US-20190315709-A1 | 4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2019-10-17 | — | — | US | disclosed |
| US-20190315709-A1 | 4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2019-10-17 | — | — | US | disclosed |
| WO-2018114700-A1 | 4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018114700-A1 | 4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2018-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315709-A1 | 4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS | TYMP, TOP2A, TOP2B | ABCG2 411/4885ALDH1A1 1963/4885LMNA 2330/4885 |
| US-10889560-B2 | 4-amino-2-pyrido-bicyclic pyrimidines and use thereof as topoisomerase II inhibitors | TYMP, TYMS, TOP2A | ABCG2 509/4885ALDH1A1 1592/4885LMNA 2107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.