Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.64 |
| ▸ | MEN1 | O00255 | 9/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6803769 | 0.84 | MEN1 (0.73) | KMT2AMEN1ALOX12MAPTLMNA | |
| SCHEMBL20303796 | 0.82 | HPGD (0.58) | ALOX12MAPTALDH1A1 | |
| SCHEMBL20303488 | 0.81 | MEN1 (0.60) | KMT2AMEN1ALOX12MAPTLMNA | |
| SCHEMBL10709186 | 0.79 | MEN1 (0.73) | KMT2AMEN1ALOX12MAPTLMNA | |
| SCHEMBL912778 | 0.79 | MEN1 (1.00) | KMT2AMEN1ALOX12MAPTLMNA | |
| SCHEMBL5800553 | 0.79 | MEN1 (0.73) | KMT2AMEN1ALOX12MAPTLMNA | |
| SCHEMBL913813 | 0.78 | MEN1 (1.00) | KMT2AMEN1ALOX12MAPTLMNA | |
| SCHEMBL20796131 | 0.77 | MEN1 (0.74) | KMT2AMEN1ALOX12MAPTLMNA | |
| SCHEMBL25826203 | 0.77 | MEN1 (0.74) | KMT2AMEN1ALOX12MAPTLMNA | |
| Methane SCHEMBL27598399 | 0.77 | MEN1 (0.97) | KMT2AMEN1ALOX12MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3555079-A1 | INHIBITORS OF MUTANT ISOCITRATE DEHYDROGENASES AND COMPOSITIONS AND METHODS THEREOF | Isocure Biosciences Inc. (US) | 2019-10-23 | — | — | EP | disclosed |
| WO-2018118793-A1 | INHIBITORS OF MUTANT ISOCITRATE DEHYDROGENASES AND COMPOSITIONS AND METHODS THEREOF | ISOCURE BIOSCIENCES INC. (US) | 2018-06-28 | — | — | WO | disclosed |