Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 12/20 | 0.36 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 10/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16610274 | 0.88 | CDC7 (0.37) | CDC7TTBK1CDK2ROCK1MAP3K14 | |
| SCHEMBL16610446 | 0.82 | CDC7 (0.42) | CDC7TTBK1CDK2ROCK1MAP3K14 | |
| SCHEMBL16610442 | 0.72 | MAP3K14 (0.46) | CDC7TTBK1CDK2ROCK1MAP3K14 | |
| SCHEMBL16610230 | 0.72 | ROCK1 (0.47) | CDC7TTBK1CDK2ROCK1MAP3K14 | |
| SCHEMBL20307364 | 0.72 | HTR6 (0.34) | — | |
| SCHEMBL16610435 | 0.72 | ROCK1 (0.44) | CDC7TTBK1CDK2ROCK1MAP3K14 | |
| SCHEMBL16610440 | 0.71 | ROCK1 (0.41) | CDC7TTBK1CDK2ROCK1MAP3K14 | |
| SCHEMBL16610444 | 0.70 | CDC7 (0.48) | CDC7TTBK1CDK2ROCK1MAP3K14 | |
| SCHEMBL16610229 | 0.69 | ROCK1 (0.45) | CDC7TTBK1CDK2ROCK1MAP3K14 | |
| SCHEMBL16610436 | 0.68 | CDC7 (0.61) | CDC7TTBK1CDK2ROCK1MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005773-B2 | 1-(4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridine derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10005773-B2 | 1-(4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridine derivatives as NIK inhibitors | MAP3K14, MAP3K15, MAP3K12 | CDC7 620/4885TTBK1 578/4885CDK2 784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.