Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | LCAT | P04180 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20308939 | 0.87 | LMNA (0.48) | SERPINE1KDM4EABL1LMNAL3MBTL1 | |
| SCHEMBL20308994 | 0.87 | PPARD (0.55) | PPARDCHRM4NOTUMCHRM2FFAR4 | |
| SCHEMBL20309127 | 0.86 | PPARD (0.52) | PPARDCHRM4NOTUMLCATCHRM2 | |
| SCHEMBL1471219 | 0.81 | PPARD (0.59) | PPARDCHRM4NOTUMLCATCHRM2 | |
| SCHEMBL20309102 | 0.79 | PPARD (0.43) | PPARDNOTUMLMNA | |
| SCHEMBL20309094 | 0.77 | NOTUM (0.40) | PPARDNOTUMSERPINE1KDM4ELMNA | |
| SCHEMBL20309163 | 0.77 | PPARD (0.61) | PPARDCHRM4NOTUMCHRM2CHRM1 | |
| SCHEMBL20309022 | 0.76 | NOTUM (0.46) | PPARDNOTUMSERPINE1 | |
| SCHEMBL20308962 | 0.76 | NOTUM (0.40) | PPARDNOTUMLMNA | |
| SCHEMBL20309033 | 0.76 | LMNA (0.42) | PPARDCHRM2CHRM1SERPINE1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805158-B1 | SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR | KALYPSYS INC (US) | 2018-06-27 | — | — | EP | disclosed |