Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 4/20 | 0.41 |
| ▸ | CDK4 | P11802 | 15/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 10/20 | 0.40 |
| ▸ | CDK2 | P24941 | 5/20 | 0.40 |
| ▸ | CDK1 | P06493 | 11/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26542499 | 0.83 | PLK4 (0.40) | PLK4CDK4CDK6CDK2CDK1 | |
| SCHEMBL2490112 | 0.83 | PLK4 (0.40) | PLK4CDK4CDK6CDK2CDK1 | |
| SCHEMBL30309559 | 0.83 | PLK4 (0.40) | PLK4CDK4CDK6CDK2CDK1 | |
| SCHEMBL23598167 | 0.82 | DCTPP1 (0.39) | PLK4CDK4CDK6CDK2CDK1 | |
| SCHEMBL25632720 | 0.81 | CDK4 (0.42) | PLK4CDK4CDK6CDK2CDK1 | |
| SCHEMBL21454993 | 0.81 | PLK4 (0.39) | PLK4CDK4CDK6CDK2CDK1 | |
| SCHEMBL28477463 | 0.80 | CDK4 (0.39) | PLK4CDK4CDK6CDK2CDK1 | |
| SCHEMBL19836561 | 0.79 | CDK4 (0.40) | PLK4CDK4CDK6CDK2CDK1 | |
| SCHEMBL23639955 | 0.79 | CDK4 (0.40) | PLK4CDK4CDK6CDK2CDK1 | |
| SCHEMBL25151531 | 0.77 | DHODH (0.39) | CDK4CDK6CDK2CCND3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024119122-A1 | CDK INHIBITORS AND METHODS AND USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-06-06 | — | — | WO | disclosed |
| WO-2023072301-A1 | PYRAZOLO[3,4-D]PYRIMIDIN-3-ONE COMPOUND AND MEDICAL USE THEREOF | 正大天晴药业集团股份有限公司 | 2023-05-04 | — | — | WO | disclosed |
| US-20210213012-A1 | COMBINATIONS OF ESTROGEN RECEPTOR DEGRADERS AND CYCLIN-DEPENDENT KINASE INHIBITORS FOR TREATING CANCER | ACCUTAR BIOTECHNOLOGY INC. | 2021-07-15 | — | — | US | disclosed |
| WO-2021133886-A1 | COMBINATIONS OF ESTROGEN RECEPTOR DEGRADERS AND CYCLIN-DEPENDENT KINASE INHIBITORS FOR TREATING CANCER | Accutar Biotechnology (US) | 2021-07-01 | — | — | WO | disclosed |
| US-10519136-B2 | Dual inhibitors of PARP1 and CDK | Accutar Biotechnology (US) | 2019-12-31 | — | — | US | disclosed |
| US-20190202806-A1 | DUAL INHIBITORS OF PARP1 AND CDK | ACCUTAR BIOTECHNOLOGY INC. | 2019-07-04 | — | — | US | disclosed |
| EP-3091008-B1 | KINASE INHIBITOR AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2018-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210213012-A1 | COMBINATIONS OF ESTROGEN RECEPTOR DEGRADERS AND CYCLIN-DEPENDENT KINASE INHIBITORS FOR TREATING CANCER | CDK3, CDK4, CDK1 | PLK4 119/4885CDK4 2/4885CDK6 16/4885 |
| US-20190202806-A1 | DUAL INHIBITORS OF PARP1 AND CDK | PARP1, PARP11, PARP12 | PLK4 134/4885CDK4 18/4885CDK6 9/4885 |
| US-10519136-B2 | Dual inhibitors of PARP1 and CDK | PARP1, PARP11, PARP12 | PLK4 134/4885CDK4 18/4885CDK6 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.