Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20246588 | 0.79 | EGFR (0.38) | EGFR | |
| SCHEMBL20310858 | 0.76 | EGFR (0.40) | EGFR | |
| SCHEMBL20311130 | 0.75 | EGFR (0.44) | EGFR | |
| SCHEMBL16623589 | 0.74 | EGFR (0.43) | EGFR | |
| SCHEMBL20311022 | 0.74 | EGFR (0.42) | EGFR | |
| SCHEMBL20246564 | 0.74 | PTGS1 (0.43) | EGFR | |
| SCHEMBL20310852 | 0.73 | EGFR (0.36) | EGFR | |
| SCHEMBL20245973 | 0.71 | EGFR (0.44) | EGFR | |
| SCHEMBL20246267 | 0.70 | EGFR (0.43) | EGFR | |
| SCHEMBL20311191 | 0.68 | EGFR (0.42) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2976339-B1 | GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-06-27 | — | — | EP | disclosed |