Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 20/20 | 0.56 |
| ▸ | PPARG | P37231 | 17/20 | 0.56 |
| ▸ | PPARD | Q03181 | 16/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2031380 | 1.00 | PPARA (0.56) | PPARAPPARGPPARDCYP1A2CYP2C9 | |
| SCHEMBL2029938 | 0.89 | PPARA (0.54) | PPARAPPARGPPARDCYP1A2CYP2C9 | |
| SCHEMBL2032852 | 0.89 | PPARA (0.54) | PPARAPPARGPPARDCYP1A2CYP2C9 | |
| SCHEMBL1934701 | 0.88 | PPARA (0.59) | PPARAPPARGPPARDCYP1A2CYP2C9 | |
| SCHEMBL12083342 | 0.86 | PPARA (0.57) | PPARAPPARGPPARDCYP1A2CYP2C9 | |
| SCHEMBL3512407 | 0.84 | PPARD (0.52) | PPARAPPARGPPARD | |
| SCHEMBL3512404 | 0.84 | PPARD (0.52) | PPARAPPARGPPARD | |
| SCHEMBL2029601 | 0.82 | PPARA (0.57) | PPARAPPARGPPARDCYP1A2CYP2C9 | |
| SCHEMBL21016831 | 0.78 | PPARA (0.53) | PPARAPPARGPPARDCYP1A2CYP2C9 | |
| SCHEMBL21016802 | 0.78 | PPARA (0.53) | PPARAPPARGPPARDCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258182-B2 | Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof | GENFIT (FR) | 2012-09-04 | — | — | US | claimed |
| US-20110136888-A1 | Substituted 1,3-Diphenylpropane Derivatives, Preparations and Uses Thereof | GENFIT (FR) | 2011-06-09 | — | — | US | claimed |
| US-20100286276-A1 | Substituted 1,3-Diphenylpropane Derivatives, Preparations and Uses Thereof | GENFIT (FR) | 2010-11-11 | — | — | US | claimed |
| US-8258182-B2 | Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof | GENFIT (FR) | 2012-09-04 | — | — | US | disclosed |
| US-8258182-B2 | Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof | GENFIT (FR) | 2012-09-04 | — | — | US | disclosed |
| US-20110136888-A1 | Substituted 1,3-Diphenylpropane Derivatives, Preparations and Uses Thereof | GENFIT (FR) | 2011-06-09 | — | — | US | disclosed |
| US-20110136888-A1 | Substituted 1,3-Diphenylpropane Derivatives, Preparations and Uses Thereof | GENFIT (FR) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136888-A1 | Substituted 1,3-Diphenylpropane Derivatives, Preparations and Uses Thereof | DPP3, DPP4, CYP3A43 | PPARA 16/4885PPARG 84/4885PPARD 15/4885 |
| US-20100286276-A1 | Substituted 1,3-Diphenylpropane Derivatives, Preparations and Uses Thereof | DPP3, DPP8, DPP4 | PPARA 11/4885PPARG 56/4885PPARD 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.