Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 9/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.46 |
| ▸ | FLT3 | P36888 | 6/20 | 0.40 |
| ▸ | KIT | P10721 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | G6PD | P11413 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20319359 | 0.89 | CSF1R (0.50) | CSF1RPDGFRBPDGFRAFLT3KIT | |
| SCHEMBL20305625 | 0.81 | CSF1R (0.74) | CSF1RPDGFRBPDGFRAFLT3KIT | |
| SCHEMBL20319358 | 0.81 | CSF1R (0.74) | CSF1RPDGFRBPDGFRAFLT3KIT | |
| SCHEMBL20319282 | 0.79 | CSF1R (0.51) | CSF1RPDGFRBPDGFRAFLT3KIT | |
| SCHEMBL20319146 | 0.77 | CSF1R (0.41) | CSF1RPDGFRBPDGFRACYP3A4TDP1 | |
| SCHEMBL20319458 | 0.76 | CSF1R (0.45) | CSF1RPDGFRBPDGFRAFLT3KIT | |
| SCHEMBL20319071 | 0.73 | CSF1R (0.50) | CSF1RPDGFRBPDGFRAKITCYP3A4 | |
| SCHEMBL20319280 | 0.73 | CSF1R (0.49) | CSF1RPDGFRBPDGFRAFLT3KIT | |
| SCHEMBL20319193 | 0.71 | CYP3A4 (0.43) | CSF1RPDGFRBPDGFRACYP3A4TDP1 | |
| SCHEMBL20319181 | 0.69 | CSF1R (0.70) | CSF1RPDGFRBPDGFRAFLT3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119387-A1 | SMALL MOLECULE INHIBITORS OF COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) AND USES THEREOF | TESARO, INC. (US) | 2018-06-28 | — | — | WO | disclosed |