Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20319144 | 0.78 | HTT (0.45) | CSF1RPDGFRBPDGFRAKDM4ECYP3A4 | |
| SCHEMBL20319145 | 0.77 | CSF1R (0.46) | CSF1RPDGFRBPDGFRAKDM4ECYP3A4 | |
| SCHEMBL25323852 | 0.74 | KDM4E (0.68) | KDM4ECYP3A4HSD17B10MAPK1TDP1 | |
| SCHEMBL4128905 | 0.70 | ALDH1A1 (0.61) | KDM4ECYP3A4HSD17B10TDP1ALDH1A1 | |
| SCHEMBL687610 | 0.70 | SMN1; SMN2 (0.66) | KDM4ECYP3A4HSD17B10TDP1ALDH1A1 | |
| SCHEMBL30421066 | 0.70 | CYP3A4 (0.45) | KDM4ECYP3A4HSD17B10TDP1ALDH1A1 | |
| SCHEMBL22392512 | 0.70 | CYP3A4 (0.45) | KDM4ECYP3A4HSD17B10TDP1ALDH1A1 | |
| SCHEMBL10721828 | 0.68 | SMN1; SMN2 (0.68) | KDM4ECYP3A4HSD17B10TDP1ALDH1A1 | |
| SCHEMBL16072315 | 0.68 | ENPP1 (0.44) | KDM4ECYP3A4MAPK1ALDH1A1MAPT | |
| SCHEMBL20319260 | 0.68 | HTT (0.67) | CYP3A4HSD17B10MAPK1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119387-A1 | SMALL MOLECULE INHIBITORS OF COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) AND USES THEREOF | TESARO, INC. (US) | 2018-06-28 | — | — | WO | disclosed |