Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 5/20 | 0.38 |
| ▸ | PPARD | Q03181 | 3/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2027258 | 0.81 | PPARA (0.35) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL1933960 | 0.81 | S1PR1 (0.45) | NPC1RAB9APPARAPPARDHAO1 | |
| SCHEMBL1935077 | 0.81 | PPARG (0.44) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL1934701 | 0.79 | PPARA (0.59) | PPARAPPARDPPARG | |
| SCHEMBL3937950 | 0.79 | HAO1 (0.42) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL1934452 | 0.77 | PPARA (0.44) | NPC1RAB9ATDP1PPARAPPARD | |
| SCHEMBL3865193 | 0.72 | NPC1 (0.64) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL15122376 | 0.70 | TDP1 (0.55) | RAB9ATDP1PPARAPPARDPPARG | |
| SCHEMBL14989117 | 0.70 | TDP1 (0.55) | RAB9ATDP1PPARAPPARDPPARG | |
| SCHEMBL14988796 | 0.70 | TDP1 (0.55) | RAB9ATDP1PPARAPPARDPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258182-B2 | Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof | GENFIT (FR) | 2012-09-04 | — | — | US | disclosed |
| US-20110136888-A1 | Substituted 1,3-Diphenylpropane Derivatives, Preparations and Uses Thereof | GENFIT (FR) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136888-A1 | Substituted 1,3-Diphenylpropane Derivatives, Preparations and Uses Thereof | DPP3, DPP4, CYP3A43 | PDE4A 219/4885PDE4B 308/4885PDE4C 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.