Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1933960 | 0.80 | S1PR1 (0.45) | HAO1NPC1RAB9ATHRBPOLB | |
| SCHEMBL1934701 | 0.79 | PPARA (0.59) | CYP1A2CYP2C9 | |
| SCHEMBL2032304 | 0.79 | PDE4A (0.39) | HAO1NPC1RAB9AKMT2ATSHR | |
| SCHEMBL3865193 | 0.78 | NPC1 (0.64) | HAO1NPC1RAB9AHPGDL3MBTL1 | |
| SCHEMBL657144 | 0.75 | NPC1 (0.55) | HAO1NPC1RAB9AKMT2AL3MBTL1 | |
| SCHEMBL2027258 | 0.74 | PPARA (0.35) | HAO1NPC1RAB9ATHRBPOLB | |
| SCHEMBL1934452 | 0.74 | PPARA (0.44) | HAO1NPC1RAB9AEPHX2NR1H4 | |
| SCHEMBL14962562 | 0.73 | TP53 (0.55) | NPC1RAB9ATP53THRBPOLB | |
| SCHEMBL7196791 | 0.72 | L3MBTL1 (0.55) | HAO1NPC1RAB9APLK1MMP2 | |
| SCHEMBL6755453 | 0.72 | HSD17B3 (0.62) | HAO1PLK1MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046715-A1 | SUBSTITUTED 1,3-DIPHENYLPROPANE DERIVATIVES, PREPARATIONS AND USES THEREOF | Genfit (FR) | 2009-04-15 | — | — | EP | claimed |
| WO-2007147879-A1 | SUBSTITUTED 1,3-DIPHENYLPROPANE DERIVATIVES, PREPARATIONS AND USES THEREOF | GENFIT (FR) | 2007-12-27 | — | — | WO | claimed |
| EP-2046715-A1 | SUBSTITUTED 1,3-DIPHENYLPROPANE DERIVATIVES, PREPARATIONS AND USES THEREOF | Genfit (FR) | 2009-04-15 | — | — | EP | disclosed |
| WO-2007147879-A1 | SUBSTITUTED 1,3-DIPHENYLPROPANE DERIVATIVES, PREPARATIONS AND USES THEREOF | GENFIT (FR) | 2007-12-27 | — | — | WO | disclosed |